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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDM4 All Species: 26.97
Human Site: S289 Identified Species: 65.93
UniProt: O15151 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15151 NP_002384.2 490 54864 S289 D D L E D S K S L S D D T D V
Chimpanzee Pan troglodytes XP_514127 490 54873 S289 D D L E D S K S L S D D T D V
Rhesus Macaque Macaca mulatta XP_001097583 479 53952 S278 D D L E D S K S L S D D T D V
Dog Lupus familis XP_536098 519 58173 S316 D D L E D S K S I S D D T D V
Cat Felis silvestris
Mouse Mus musculus O35618 489 54974 S288 D D L E D S R S L S D D T D V
Rat Rattus norvegicus Q5XIN1 490 55202 S289 D D L E D S K S L S D D T D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507004 516 57467 C315 D D L E D S Q C L S D D T D T
Chicken Gallus gallus XP_417957 481 54617 C285 H D F E D S Q C L S D D T D T
Frog Xenopus laevis Q7ZYI3 475 53387 S285 D D L D D T Q S L S E D T D T
Zebra Danio Brachydanio rerio Q7ZUW7 496 55223 C294 E Q E E D S Q C L S D D T D T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 92.8 88.8 N.A. 84 84.2 N.A. 68.5 59.7 47.1 47.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.8 94.4 90.7 N.A. 90.8 90.1 N.A. 78.6 73 65.9 62.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 100 N.A. 80 66.6 66.6 60 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 86.6 73.3 93.3 73.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 30 0 0 0 0 0 0 0 % C
% Asp: 80 90 0 10 100 0 0 0 0 0 90 100 0 100 0 % D
% Glu: 10 0 10 90 0 0 0 0 0 0 10 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 50 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 80 0 0 0 0 0 90 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 0 40 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 90 0 70 0 100 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 10 0 0 0 0 0 0 100 0 40 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 60 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _